10-4446
GLPG3970
Size
£197.00
- SKU:
- 10-4446
- Physical State:
- Solid
- Molecular Weight:
- 504.51
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2403733-82-2
- Immunogen:
- Kinase
- Extra Details:
- GLPG3970 is a potent and selective (against a panel of 372 kinases) SIK2/3 inhibitor (IC50s: SIK2 = 7.8 nM, SIK3 = 3.8 nM).1 It reduced THFA Alpha and increased IL-10 levels in an LPS challenge model in mice and displayed efficacy in a mouse model of colitis. GLPG3970 promoted reprogramming of human myeloid cells toward an anti-inflammatory phenotype, reprogrammed monocyte-dendritic differentiation toward stable tolerogenic phenotypes, and suppressed T-cell activation.2 It also displayed efficacy in mouse models of psoriasis and arthritis.
- Shipping Conditions:
- Ambient