10-4421
PZL-A
Size
£158.00
- SKU:
- 10-4421
- Physical State:
- Solid
- Molecular Weight:
- 368.82
- Purity:
- >97%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 3068830-89-4
- Immunogen:
- DNA
- Extra Details:
- PZL-A is a first-in-class activator of mammalian mitochondrial DNA (mtDNA). AC50's: 160 nM for A467T mutant; 20 nM for G848S mutant. mtDNA, which encodes essential protein subunits of the oxidative phosphorylation complexes, is replicated by DNA polymerase POLG Gamma. PZL-A restores function to mutant POLG Gamma via binding to an allosteric site between the catalytic subunits POLG GammaA and POLG GammaB. An important new tool for studying mitochondrial disorders.
- Shipping Conditions:
- Ambient