XL413 HCl

Size

£158.00

SKU:: 10-4414
Physical State:: Solid
Molecular Weight:: 326.18
Purity:: >98%
Purification:: HPLC Purified
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 2062200-97-7
Immunogen:: Kinase
Extra Details:: XL413 is a potent (IC50 = 4.8 nM) ATP-competitive inhibitor of the important DNA replication initiation kinase Cdc7 (DDK).1 It increases the efficiency of homology directed DNA repair in CRISPR-Cas9 gene editing.2 XL413 acted synergistically with other chemotherapy agents in various cancer models.3-5