ARN25499

Size

£173.00

SKU:: 10-4412
Physical State:: Solid
Molecular Weight:: 390.49
Purity:: 99%
Purification:: HPLC Purified
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
Immunogen:: GTPase
Extra Details:: ARN25499 is a novel Cdc42 GTPase interaction inhibitor. It inhibits the interaction between Cdc42 and its downstream effectors (i.e PAK) instead of the Cdc42-GEF interaction. ARN25499 displayed activity against four melanoma cancer cell lines (IC50s: SKM28 13.5 uM, SKMeI3 8.1 uM, WM3248 12.8 uM, A375 9.7 uM) and one colon cancer line (IC50 = 11.2 uM SW480). It also displayed good pharmacokinetics in mice. ARN25499 also showed in vivo efficacy in melanoma PDX tumors in NSG mice at 10mg/kg.