10-4402
ZT-1a
Size
£187.00
- SKU:
- 10-4402
- Physical State:
- Solid
- Molecular Weight:
- 445.72
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 212135-62-1
- Immunogen:
- Kinase
- Extra Details:
- ZT-1a is a non-ATP competitive inhibitor (IC50 = 44.3 uM @ 0.01 mM ATP) of SPAK kinase (STK39), a master regulator of cation-Cl- cotransporters.1 It attenuated cerebral edema, protected against ischemic brain damage, and improved post-ischemic neurological outcomes in mouse models of stroke.1,2 ZT-1a showed neuroprotective effects in mouse models of vascular dementia3 and multiple sclerosis4. It inhibited the progression of hepatocellular carcinoma in rodent models and showed synergistic effects with PD-1 antibodies by helping to prevent tumor microenvironment immune exhaustion.5
- Shipping Conditions:
- Ambient