10-4391
Nerandomilast
Size
£177.00
- SKU:
- 10-4391
- Additional Names:
- BI 1015550
- Physical State:
- Solid
- Molecular Weight:
- 448.97
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1423719-30-5
- Immunogen:
- PDE (Phosphodiesterase)
- Extra Details:
- Nerandomilast is a potent and selective inhibitor of phosphodiesterase 4B (IC50's: PDE4A = 248 nM, PDE4B = 10 nM, PDE4C = 8,700 nM, PDE4D = 91 nM, PDE7A = 14 uM, PDE3A = 120 uM, PDE1C = 46 uM).1 It inhibited TNFA Alpha release (IC50 = 35 nM) and IL-2 release (IC50 = 9 nM) in human PBMCs. Nerandomilast has potent anti-inflammatory activity and displayed efficacy in mouse models of lung fibrosis.1,2 Approved for the treatment of idiopathic pulmonary fibrosis.
- Shipping Conditions:
- Ambient