10-4381
LGK974
Size
£168.00
- SKU:
- 10-4381
- Additional Names:
- WNT974
- Physical State:
- Solid
- Molecular Weight:
- 396.45
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1243244-14-5
- Immunogen:
- Acyltransferase
- Extra Details:
- LGK974 is a potent and selective inhibitor of Porcupine (IC50 = 1 nM). Inhibits Wnt signaling (IC50 = 0.4 nM) in vitro and in vivo.1 It displays efficacy in several cancer models including glioblastoma2,6, squamous cell3, renal cell carcinoma4, and non-small cell lung5. LGK974 reprogrammed the immune suppressive tumor microenvironment in a mouse model of glioblastoma to increase antitumor immune responses.6 It also potentiated anti-PD1 therapy by increasing DC3-like dendritic cells and decreasing myeloid suppressor cells. LGK974 attenuated myocardial ischemia-reperfusion injury by reducing inflammatory responses.7
- Shipping Conditions:
- Ambient