10-4380
Icilin
Size
£163.00
- SKU:
- 10-4380
- Additional Names:
- AG 3-5
- Physical State:
- Solid
- Molecular Weight:
- 311.29
- Purity:
- >98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 36945-98-9
- Immunogen:
- Ion channel
- Extra Details:
- Icilin is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 uM for CRM1, rat orthologue of TRPM8).1 Agonist at TRPM8 (EC50 = 0.2 uM)2 and ANKTM1(TRPA1)3. Agonist effects require Ca2+ and are pH dependent.2,4 Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.5
- Shipping Conditions:
- Ambient