10-4369
ADRIANA
Size
£177.00
- SKU:
- 10-4369
- Physical State:
- Solid
- Molecular Weight:
- 237.29
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 719277-27-7
- Immunogen:
- GPCR
- Extra Details:
- ADRIANA is potent antagonist (IC50 = 1.71 uM) of the A Alpha2B adrenoceptor with selectivity over A Alpha2A and A Alpha2C. It promotes noradrenaline release in the murine spinal dorsal horn leading to potent analgesic effects via stimulation of the A Alpha2A-dependent pain inhibitory pathway. Active in various nociceptive pain models in both mice and non-human primates. Orally bioavailable with no adverse cardiac/circulatory system effects.
- Shipping Conditions:
- Ambient