D159687

Size

POA

SKU:: 10-4367
Physical State:: Solid
Molecular Weight:: 366.85
Purity:: >97%
Purification:: HPLC Purified
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 1155877-97-6
Immunogen:: PDE (Phosphodiesterase)
Extra Details:: D159687 is a potent (IC50 = 28 nM human PDE4D) and selective allosteric inhibitor of phosphodiesterase 4D (PDE4D) that increases cAMP levels and displays efficacy in cognition tests in mice and monkeys.1,2 It reversed cognitive deficits in a mouse model of traumatic brain injury.3 D159687 induced weight and fat mass loss in aged mice without changing lean mass.4 It also mitigated liver fibrosis by suppressing the expression of inflammatory and profibrogenic genes.5