10-4359
Prexasertib
Size
POA
- SKU:
- 10-4359
- Additional Names:
- LY2606368
- Physical State:
- Solid
- Molecular Weight:
- 438.32
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1234015-54-3
- Immunogen:
- Kinase
- Extra Details:
- Prexasertib is a potent inhibitor of CHK1 (IC50 = <1 nM) and CHK2 (IC50 = 8 nM).1 It also inhibits RSK1 (IC50 = 9 nM).1 It displayed efficacy in various cancer models alone and in combination with other agents including anti-PD-L1 therapy.2-6 It promoted neuroprotection, axon regeneration, and functional recovery after CNS injury.7 The cytotoxic effects of prexasertib have been attributed to dual inhibition of CHK1 and AMPK.8
- Shipping Conditions:
- Ambient