10-4325
Buparlisib
Size
£158.00
- SKU:
- 10-4325
- Additional Names:
- BKM-120|NVP-BKM120
- Physical State:
- Solid
- Molecular Weight:
- 410.39
- Purity:
- 99%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 944396-07-0
- Immunogen:
- Cytoskeleton|Kinase
- Extra Details:
- Potent pan-Class I PI3-kinase inhibitor (IC50's: p110A Alpha = 52 nM, p110B Beta = 166 nM, p110D Delta = 116 nM. P110g = 262 nM).1,2 It inhibited microtubule dynamics at in vitro concentrations >1uM and doses above 50mg/kg in mice.3 Buparlisib lead to a precipitous drop in DNA synthesis in a mouse model of BRCA1-linked triple-negative breast cancer with less affect in normal tissue.4
- Shipping Conditions:
- Ambient