BI 749327

Size

£177.00

SKU:: 10-4318
Physical State:: Solid
Molecular Weight:: 442.44
Purity:: 98%
Purification:: HPLC Purified
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 2361241-23-6
Immunogen:: Ion channel
Extra Details:: Potent (IC50 = 13 nM mouse TRPC6, 19 nM human TRPC6) and selective (85-fold over TRPC3, 42-fold over TRC7) orally available blocker of TRPC6.1 It suppressed interstitial fibrosis and associated molecular signaling in mouse heart and kidney disease models. BI 749327 reversed established pulmonary hypertension by 50% via regression of pulmonary remodeling in a mouse model.2