10-4297
K-975
Size
£134.00
- SKU:
- 10-4297
- Physical State:
- Solid
- Molecular Weight:
- 287.74
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2563855-03-6
- Immunogen:
- Transcription factor
- Extra Details:
- K-975 is a covalent inhibitor of YAP/TAZ-TEAD signaling. It binds to the palmitate-binding pocket of TEAD preventing its association with YAP/TAZ.1 K-975 inhibited proliferation of NF2-non-expressing mesothelioma cell lines. K-975 promoted liver progenitor cell to hepatocyte differentiation via suppression of YAP signaling.2 It sensitized YAP-expressing RET-aberrant cancer cells to RET kinase inhibitors.3
- Shipping Conditions:
- Ambient