10-4289
TP-040
Size
£177.00
- SKU:
- 10-4289
- Additional Names:
- O-GlcNAcase-IN-1
- Physical State:
- Solid
- Molecular Weight:
- 286.38
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2757254-99-0
- Immunogen:
- Glycosylation
- Extra Details:
- TP-040 is a potent and brain-penetrant inhibitor (IC50 = 46 nM) of O-GlcNAcase (OGA). OGA catalyzes the cleavage of O-linked N-acetylglucosamine from serine and threonine residues. On tau proteins, this leads to a less soluble and less stable protein form that is prone to aggregation. TP-040 is an interesting new tool for studying the effects of tau protein aggregation in neurodegenerative diseases.
- Shipping Conditions:
- Ambient