10-4276
Y-320
Size
£149.00
- SKU:
- 10-4276
- Physical State:
- Solid
- Molecular Weight:
- 505.02
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 288250-47-5
- Extra Details:
- Y-320 is an inhibitor of IL-17 production (IC50 = 20 - 60 nM in CD4 T cells).1 It significantly inhibited the development and progression of arthritis and joint destruction in collagen-induced arthritis models. Y-320 acted synergistically with other chemotherapeutic agents to overcome multidrug resistance.2 It also enhances premature termination codon (PTC) readthrough resulting in increased protein levels and protein synthesis.3 Y-320 also acts as a potent oral sialylation inhibitor (IC50 = 200 nM in PDAC cells).4 It suppressed A Alpha-2,3/2,6-sialylation inhibiting PDAC tumor growth and remodeling the tumor microenvironment. Y-320 acted synergistically with anti-PD-1 therapy to overcome immune checkpoint blockade resistance.
- Shipping Conditions:
- Ambient