10-4261
PF-4136309
Size
£173.00
- SKU:
- 10-4261
- Additional Names:
- INCB8761
- Physical State:
- Solid
- Molecular Weight:
- 568.60
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1341224-83-6
- Immunogen:
- GPCR
- Extra Details:
- PF-4136309 (1341224-83-6) is a potent (hIC50 = 5.2 nM, mIC50 = 13 nM, rIC50 = 17 nM) and selective inhibitor of CCR2.1 PF-4136309 significantly decreased inflammatory monocytes in a mouse model of pancreatic cancer.2 In combination therapy with the FOLFIRINOX regimen, PF-4136309 reversed immune suppression in the tumor microenvironment causing an influx of tumor infiltrating lymphocytes leading to overall enhanced efficacy in a phase 1b study.3
- Shipping Conditions:
- Ambient