CGP-37157

Size

£168.00

SKU:: 10-4250
Physical State:: Solid
Molecular Weight:: 324.22
Purity:: 99%
Storage Conditions:: RT
Supplier:: Focus Biomolecules
CAS Number:: 75450-34-9
ABP:: No Import Docs
Immunogen:: Ion channel
Extra Details:: Inhibits the mitochondrial Na+-Ca2+ exchanger (NCX) in isolated heart mitochondria, IC50=0.36 uM.1 Does not inhibit the plasmalemmal NCX.2 Also inhibits voltage-gated Ca2+ channels in intact cells and therefore its use in cellular studies must employ adequate controls.3 Prevents sudden death in a Guinea pig model of heart failure.4 Displays pronounced cytoprotective effects in chromaffin cells5 and in neuronal injury models.6 Blood-brain barrier permeant.