10-4202
Siramesine
Size
£173.00
- SKU:
- 10-4202
- Additional Names:
- Lu 28-179
- Physical State:
- Solid
- Molecular Weight:
- 454.59
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 147817-50-3
- Immunogen:
- ER/Golgi|Lysosome
- Extra Details:
- Siramesine (Lu 28-179) is a 2 selective agonist (IC50's: 1 = 17nM, 2 = 0.2nM).1 It produced non-sedating potent and long-last anxiolytic effects in rodents.2 Siramesine induced caspase-independent programmed cell death in various cancer cell lines via increased levels of ROS and lysosomal leakage.3,4,5 Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine.6
- Shipping Conditions:
- Ambient