PITSTOP2

Size

£158.00

SKU:: 10-4195
Physical State:: Solid
Molecular Weight:: 473.36
Purity:: >98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 1332879-52-3
Immunogen:: Cytoskeleton|GTPase
Extra Details:: PITSTOP2 inhibits clathrin-mediated endocytosis via blockade of endocytic ligand association with the clathrin terminal domain leading to clathrin coat assembly inhibition.1 It was able to cause a collapse of the nucleocytoplasmic permeability barrier and a reduction of Importin-B Beta binding.2 PITSTOP2 reduced viability in HeLa cells by trapping dividing cells in metaphase through loss of mitotic spindle integrity.3