10-4177
XI-011
Size
£153.00
- SKU:
- 10-4177
- Additional Names:
- NSC146109
- Physical State:
- Solid
- Molecular Weight:
- 316.85
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 59474-01-0
- Immunogen:
- Transcription factor
- Extra Details:
- XI-011 activates p53 by inhibiting expression of one of its negative regulators, MDM4 (MDMX).1 It was able to induce apoptosis in MCF-7 breast cancer cells. XI-011 acted synergistically with cisplatin in inducing apoptosis in head and neck cancer cells.2 It also induced apoptosis in several cervical cancer in vitro and in vivo.3 XI-011 displayed efficacy in treating lung fibrosis in an MDM4-dependent manner.4
- Shipping Conditions:
- Ambient