10-4175
PRIMA-1MET
Size
£149.00
- SKU:
- 10-4175
- Additional Names:
- APR-246
- Physical State:
- Solid
- Molecular Weight:
- 199.25
- Purity:
- 95%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 5291-32-7
- Immunogen:
- Glutathione|Transcription factor
- Extra Details:
- PRIMA-1MET reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1 It induces p53-dependent mitochondrial apoptosis via activation of caspase-2.2 PRIMA-1MET showed significant antitumor activity in multiple myeloma via activation of p733 and had previously been shown to target p53 family members p63 and p734. Tumor cell death by PRIMA-1MET has been also shown to be caused by glutathione depletion and induced ROS production in a p53 independent manner.5-7 PRIMA-1MET probably induces tumor cell death by both reactivating mutant p53 and inhibiting cellular thiol-dependent redox systems.8
- Shipping Conditions:
- Ambient