10-4165
Belumosudil
Size
£144.00
- SKU:
- 10-4165
- Additional Names:
- KD025|SLx-2119
- Physical State:
- Solid
- Molecular Weight:
- 452.52
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 911417-87-3
- ABP:
- No Import Docs
- Immunogen:
- Kinase
- Extra Details:
- Belumosudil is a selective inhibitor of Rho kinase 2 (ROCK2) - IC50's: ROCK2 = 105 nM, ROCK1 = 24 uM in enzyme assays.1 It downregulated the ability of T cells to secrete IL-21 and IL-17, but not IFN-g, in response to T cell stimulation in vitro via a STAT3-dependent mechanism.2 Belumosudil ameliorated graft-versus-host disease in multiple models3,4 and was recently approved by the FDA for the treatment of GVHD (July 2021). It has also been shown to suppress adipogenesis.5-7 Suppression of adipocyte differentiation is mediated via casein kinase 2 inhibition (IC50 = 50 nM) and not ROCK2 inhibition.8
- Shipping Conditions:
- Ambient