10-4142
Cediranib
Size
£163.00
- SKU:
- 10-4142
- Additional Names:
- AZD2171
- Physical State:
- Solid
- Molecular Weight:
- 450.51
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 288383-20-0
- Immunogen:
- Kinase
- Extra Details:
- Cediranib is a highly potent (IC50 = <1 nM) inhibitor of VEGFR-2.1 It also inhibits VEGFR-1, VEGFR-3, c-Kit, and PDGFRB Beta (IC50s respectively: 5 nM, 3 nM, 2nM, and 5 nm). It displays broad-spectrum activity in various human tumor models. Cediranib normalized tumor vasculature decreasing permeability, increasing blood perfusion, and allowing better drug delivery in glioblastoma patients.2,3 It enhanced transcription of MHC-I leading to enhanced CD8+ T cell infiltration and improved efficacy of anti-PD-L1 therapy.4
- Shipping Conditions:
- Ambient