RU.521

Size

£192.00

SKU:: 10-4140
Physical State:: Solid
Molecular Weight:: 415.23
Purity:: 98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 2262452-06-0
Immunogen:: STING
Extra Details:: Inhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-stranded DNA.1,2 IC50 = 0.70 uM in dsDNA-stimulated RAW macrophages1 and ~0.80 uM in wild type human THP-1 cells2. It is selective for cGAS with no targeting of IFNB1 protein, interferon receptors, or downstream signaling components of the JAK/STAT pathway. RU.521 was able to significantly increase cardiac output in a mouse model of sepsis.3 Active in both mouse and human cell lines.