10-4138
GNS561
Size
£177.00
- SKU:
- 10-4138
- Additional Names:
- Ezurpimtrostat HCl
- Physical State:
- Solid
- Molecular Weight:
- 459.46
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1914148-73-4
- Immunogen:
- STING
- Extra Details:
- GNS561 induces lysosomal dysregulation leading to inhibition of autophagy.1 It displayed efficacy against intrahepatic cholangiocarcinoma1 and hepatocellular carcinoma2. GNS561 acted as an anti-fibrotic agent against liver fibrosis in a rat model.3 GNS561-induced cell death is partially caused by inhibition of palmitoyl-protein thioesterase 1 (PPT1) leading to lysosomal dysfunction.4 GNS561 treatment of prostate and ovarian cancer models enhanced STING expression and activation via PPT1 inhibition leading to infiltration of cytotoxic T cells.5 GNS561 represents a potentially novel immunotherapy for cold tumors.
- Shipping Conditions:
- Ambient