10-4125
P22077
Size
£168.00
- SKU:
- 10-4125
- Physical State:
- Solid
- Molecular Weight:
- 315.32
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1247819-59-5
- Immunogen:
- DUB (Deubiquitinating enzyme)
- Extra Details:
- P22077 is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50 = 8 uM) and the closely related USP47.1,2 It destabilizes claspin, a scaffolding protein involved in regulating Chk1 kinase, a DNA damage response enzyme.2 P22077 inhibits neuroblastoma growth via induction of p53-mediated apoptosis.3 N-Myc was destabilized by P22077 inhibition of USP7 in human neuroblastoma cells.4 It was able to stabilize p53 levels in conjunction with an Mdm2 inhibitor (Nutlin-3, Cat# 10-1350) in HCT116 colorectal carcinoma cells.5
- Shipping Conditions:
- Ambient