10-4124
Alisertib
Size
£163.00
- SKU:
- 10-4124
- Additional Names:
- MLN8237
- Physical State:
- Solid
- Molecular Weight:
- 518.92
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1028486-01-2
- Immunogen:
- Kinase
- Extra Details:
- Alisertib (MLN8237) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc degradation2 in Myc amplified neuroblastomas3 and p53-mutant human hepatocellular carcinoma cell4. Alisertib has been found to induce apoptosis and autophagy in breast cancer5 and melanoma6 cells via suppression of activation of the p38 MAPK pathway.
- Shipping Conditions:
- Ambient