N6022

Size

£158.00

SKU:: 10-4103
Physical State:: Solid
Molecular Weight:: 414.46
Purity:: >98%
Purification:: HPLC Purified
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 1208315-24-5
Immunogen:: Glutathione
Extra Details:: N6022 is a potent and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) - IC50 = 20 nM1, 8 nM2. It demonstrated significant efficacy in a mouse models of ovalbumin-induced asthma, chronic obstructive pulmonary disease, and irritable bowel syndrome. N6022 was able to attenuate experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis) via selective inhibition of pro-inflammatory CD4+ cells (TH1/TH17) while upregulating anti-inflammatory subsets of CD4+ cells (TH2/Treg) without causing lymphopenia.3