10-4102
Preladenant
Size
£168.00
- SKU:
- 10-4102
- Additional Names:
- SCH 420814
- Physical State:
- Solid
- Molecular Weight:
- 503.57
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 377727-87-2
- Immunogen:
- GPCR
- Extra Details:
- Preladenant is a potent (Ki = 1.1nM) and selective (>1000-fold over other adenosine receptors) adenosine A2A antagonist.1 It has shown efficacy in rodent and primate models of Parkinsons disease without inducing dyskinesias and displays antidepressant effects.1-3 It has been shown that activation of the adenosine A2A receptor blocks the activation of immune cells and increases the number of regulatory T-cells.4-6 Currently in clinical trials as combination therapy with pembrolizumab.7
- Shipping Conditions:
- Ambient