10-4101
CPI-444
Size
£192.00
- SKU:
- 10-4101
- Additional Names:
- Ciforadenant
- Physical State:
- Solid
- Molecular Weight:
- 407.43
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1202402-40-1
- Immunogen:
- GPCR
- Extra Details:
- CPI-444 (1202402-40-1) is a potent (Ki = 3.54 nM) and selective adenosine A2A receptor antagonist. It blocked the induction of cAMP induced by NECA in HEK-293 cells with an IC50 = 17.03 nM. CPI-444 monotherapy or in combination with anti-PD-1, anti-PD-L1, and anti-CTLA-4 induced T-cell-mediated tumor responses, inhibited tumor growth, and enabled antitumor immune memory.1,2 Currently in clinical trials for multiple cancers.3
- Shipping Conditions:
- Ambient