10-4092
SKLB-D18
Size
£187.00
- SKU:
- 10-4092
- Physical State:
- Solid
- Molecular Weight:
- 472
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Immunogen:
- Kinase
- Extra Details:
- SKLB-D18 is a first-in-class potent dual ERK1/2 and ERK 5 inhibitor (IC50's: ERK1 = 39 nM, ERK2 = 40 NM, ERK5 = 60 nM) and is highly selective against a panel of 380 kinases. It exhibited good activity against MDA-MB-231 (IC50 = 0.93 uM) and MDA-MB-468 (IC50 = 1.05 uM) cells. SKLB-D18 inhibited activation of ERK1/2/5 downstream components p-ERK5, p-RSK90, p-c-Myc, and c-MYC. It was also able to induce autophagy-dependent cell death and ferroptosis in triple negative breast cancer cells. Active in mouse triple negative breast cancer xenografts.
- Shipping Conditions:
- Ambient