LW6

Size

£197.00

SKU:: 10-4083
Physical State:: Off-white to light gray solid
Molecular Weight:: 435.52
Purity:: >98%
Purification:: HPLC Purified
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 934593-90-5
Immunogen:: Dehydrogenase (GAPDH, GPDH, IMPDH, PHGDH, LDH, DHODH, ALDH, GDH, IDH, UGDH, DPD, DHPDH, KGDH, PDH, and MDH)
Extra Details:: LW6 is an inhibitor of malate dehydrogenase (MDH) (IC50's: MDH1 = 1.1 uM; MDH2 = 6.3 uM).1,2 It inhibits Hypoxia-Inducible Factor-1 (HIF-1) by a variety of reported mechanisms.3-5 LW6 displayed antitumor properties in hepatocellular6 and pancreatic cancer7 cell lines. It promoted rat locomotor function after spinal cord injury via reduction of neuroinflammation.8