10-4082
UNC9435
Size
£197.00
- SKU:
- 10-4082
- Physical State:
- Solid
- Molecular Weight:
- 520.54
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 3091640-25-1
- Immunogen:
- Kinase
- Extra Details:
- UNC9435 is a potent dual inhibitor of TYRO3 (IC50 = 3.7 nM) and MERTK (IC50 = 1.1 nM), TAM family kinases with roles in oncogenesis and innate immunity.1 Displays 46-fold selectivity over the TAM kinase AXL and 120-fold selectivity over FLT3. It inhibited colony formation in H1650 and H1975 NSCLC cell lines and inhibited efferocytosis.
- Shipping Conditions:
- Ambient