10-4075
SIC5-6
Size
£149.00
- SKU:
- 10-4075
- Physical State:
- Solid
- Molecular Weight:
- 581.47
- Purity:
- 97%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2410846-16-9
- Immunogen:
- Cytoskeleton|Protease
- Extra Details:
- Separase is a cysteine protease that triggers chromosome segregation during mitosis and is highly overexpressed in many cancers. SIC5-6 is an inhibitor of separase with no inhibition of the related protease caspase-1 in vitro. HeLa cells with dysregulated separase activity showed severe chromosome segregation defects on treatment with 30 uM SIC5-6 indicating a potential attractive new chemotherapeutic target.
- Shipping Conditions:
- Ambient