10-4068
SR3335
Size
£177.00
- SKU:
- 10-4068
- Additional Names:
- ML176
- Physical State:
- Solid
- Molecular Weight:
- 405.33
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 293753-05-6
- Immunogen:
- Retinoid receptor and related|Transcription factor
- Extra Details:
- SR3335 (293753-05-6) is a selective RORA Alpha partial inverse agonist (IC50 = 480 nM) - displays no activity at RORB Beta, RORG Gamma, or FXR.1 It was able to suppress gluconeogenesis in diet-induced obese mice. SR3335 was able to upregulate uncoupling protein 1 (UCP1), a unique mitochondrial protein devoted to thermogenesis, in wild type mice leading to decreased body weight and fat mass.2,3 It inhibited the development of mouse and human TH17 cells in vitro and in vivo leaving thymic T cells intact.4 SR3335's ability to block pathogenic, but not protective TH17 cell function makes it an important new tool in the study of TH17-mediated inflammatory and autoimmune diseases.
- Shipping Conditions:
- Ambient