10-4066
SR1078
Size
£168.00
- SKU:
- 10-4066
- Physical State:
- Solid
- Molecular Weight:
- 431.26
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1246525-60-9
- Immunogen:
- Retinoid receptor and related|Transcription factor
- Extra Details:
- Agonist of the orphan nuclear receptors RORA Alpha and RORG Gamma.1 It attenuated intrapancreatic pathological changes in mouse models of chronic pancreatitis via restoration of the circadian stabilizing loop.2 SR1078 stimulation of RORA Alpha restored clock protein BMAL1 expression and oscillation and blocked MYCN-mediated neuroblastoma growth.3 It reduced repetitive behavior is a mouse model of autism suggesting a potential therapeutic pathway for the disorder.4 SR1078 treatment lead to an increase in p53 levels and increased apoptosis in HepG2 cells.5
- Shipping Conditions:
- Ambient