TETi76 ester

Size

£173.00

SKU:: 10-4041
Physical State:: Oil
Molecular Weight:: 216.23
Purity:: >98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 1451750-73-4
Immunogen:: DNA|Nucleic acid methylation
Extra Details:: Cell permeable inhibitor of TET dioxygenases (IC50s: TET1 = 1.5 uM; TET2 = 9.4 uM; TET3 = 8.8 uM), indirect (via cytosine hydroxymethylation) erasers of DNA methylation.1,2 TET2 is frequently mutated in myeloid neoplasms - TET2 inhibition with TETi76 restricted clonal outgrowth and induced apoptosis of TET2 mutants but not normal hematopoietic precursor cells in vitro and in vivo.