iJMJD6

Size

£173.00

SKU:: 10-4039
Additional Names:: WL12
Physical State:: Solid
Molecular Weight:: 277.28
Purity:: >98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 899548-78-8
Immunogen:: Protein demethylase
Extra Details:: Inhibitor of the arginine demethylase JMJD6 (IC50 = 220 nM) with selectivity over other JmjC domain-containing proteins.1 Exhibited antiproliferative effects in HeLa (EC50 = 1.49 uM), SMCC7721 (EC50 = 9.37 uM), and MCF7 (EC50 = 9.53 uM) cells.2 Displayed no cytotoxicity towards normal cervical, liver, and breast epithelial cells. iJMJD6 significantly suppressed tumor growth in a HeLa, SMCC7721, MCF7, MDA-MB-231, U87, and HCT116 mouse xenograft models.2