10-4038
iBAP-II
Size
£182.00
- SKU:
- 10-4038
- Physical State:
- Solid
- Molecular Weight:
- 308.33
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1013813-81-4
- ABP:
- No Import Docs
- Immunogen:
- DUB (Deubiquitinating enzyme)
- Extra Details:
- Inhibitor of the H2AK119 deubiquitinase BAP1 (IC50 = 0.092 ug/ml). It is selective for BAP1 over UCHL5, USP5,7,8, TNFAIP3-catalytic domain, USP2-catalytic domain, Otubain-1, and Ataxin3. iBAP-II disrupted the BAP1/ASXL3/BRD4 axis via induction of protein degradation of the ASXL3 scaffold protein in the small cell lung cancer lines NCI-H1963, NCI-H748, and NCI-H1882. It also suppressed expression of the master transcription factor ASCL1 in NCI-H1963 small cell lung cancer cells. iBAP-II significantly delayed disease progression in a small cell lung cancer xenograft mouse model.
- Shipping Conditions:
- Ambient