10-4008
SR0987
Size
£163.00
- SKU:
- 10-4008
- Physical State:
- Solid
- Molecular Weight:
- 397.70
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 303126-97-8
- Immunogen:
- Retinoid receptor and related|Transcription factor
- Extra Details:
- RORG Gammat is a T cell specific isoform of ROR that is a key transcription factor for initiating the differentiation of Th17 and Tc17 cells. SR0987 (303126-97-8) is a RORG Gammat agonist that drives proliferation of Th17 cells and decrease levels of the immune checkpoint protein PD-1. In a Ga14 UAS-Luc cotransfection system, SR0987 induced reporter gene expression (EC50 = 800nM). Treatment of human Jurkat T cells with SR0987 resulted in decreased cell surface PD-1 expression. RORG Gammat agonists may synergize with current anti-PD-1 therapy and represent a new potential class of cancer immunotherapeutic.
- Shipping Conditions:
- Ambient