MPEP HCl

Size

£139.00

SKU:: 10-4007
Physical State:: Solid
Molecular Weight:: 229.71
Purity:: 98%
Purification:: HPLC Purified
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 219911-35-0
Immunogen:: GPCR
Extra Details:: MPEP is a potent (IC50 = 36 nM for quisqualate-stimulated phosphoinositide hydrolysis) and selective (over mGlu1b, -2, -3, -4a, -6, -7b, and -8a) antagonist of the metabotropic glutamate receptor subtype 5 (mGlu5).1 It is a positive allosteric modulator of human mGlu4.2 MPEP inhibition of mGlu5 has been studied for the treatment of many CNS disorders including Parkinson's3,4, Fragile X syndrome5, and addiction6.