Pridopidine

Size

£177.00

SKU:: 10-4003
Additional Names:: ACR16
Physical State:: Solid
Molecular Weight:: 281.41
Purity:: 98%
Storage Conditions:: RT
Supplier:: Focus Biomolecules
CAS Number:: 346688-38-8
Immunogen:: ER/Golgi
Extra Details:: Pridopidine is being studied as a potential treatment for Huntington's disease, Parkinson's disease, and schizophrenia based on its locomotor stabilizing and antipsychotic-like effects.1,2 It was, unusually, able to reverse both hypo- and hyperdopaminergia depending on local dopamine concentrations without inducing catalepsy. This was originally attributed to functional dopamine D2 antagonism with fast on/off kinetics ("dopamine stabilizer").3 More recent studies have attributed pridopidine's effects to its being a more potent sigma-1 ligand than a D2 ligand.4,5 Displays neuroprotective/restorative effects6,7 and ameliorates central features of amyotrophic lateral sclerosis pathology8 in a sigma-1-mediated manner