10-3991
ANP-230
Size
£177.00
- SKU:
- 10-3991
- Additional Names:
- DSP-2230
- Physical State:
- Solid
- Molecular Weight:
- 419.41
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1233231-30-5
- Immunogen:
- Ion channel
- Extra Details:
- ANP-230 is a state-independent selective inhibitor of sodium channels Nav1.7, 1.8, and 1.9 (IC50's respectively: 7.1 uM, 11.4 uM, and 6.7 uM).1 Selective over the cardiac Nav1.5 channel (IC50 = 156 um). It potently reduced neuronal excitability in rat DRG neurons.3 ANP-230 reduced pain sensitivity in a mouse episodic pain syndrome model.2 It demonstrated efficacy in several models of neuropathic and inflammatory pain with no motor function impairment.3 It also potentiated the anti-allodynic effects of pregabalin and morphine when administered concurrently.3
- Shipping Conditions:
- Ambient