YL-365

Size

£177.00

SKU:: 10-3988
Additional Names:: 1-[4-(3-Chlorophenyl)benzoyl]-4-[[2-(4-phenylmethoxyphenyl)acetyl]amino]piperidine-4-carboxylic acid
Physical State:: Solid
Molecular Weight:: 583.08
Purity:: >98%
Purification:: HPLC Purified
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
Immunogen:: GPCR
Extra Details:: YL-365 is a potent (IC50 = 17 nM) and selective antagonist of GPR34, a GPCR for lysophosphatidylserine.1 GPR34 is highly expressed in various immune cells and has been implicated in several types of cancer.2 YL-365 showed no activity against various other GPCRs as well as a panel of 378 kinases. It alleviated hyperalgesia in a mouse model of neuropathic pain via downregulation of iNOS in M1 microglia without any toxicity.