10-3976
RMC-6236
Size
£144.00
- SKU:
- 10-3976
- Additional Names:
- Daraxonrasib
- Physical State:
- Solid
- Molecular Weight:
- 811.06
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2765081-21-6
- ABP:
- No Import Docs
- Immunogen:
- GTPase|Molecular glue
- Extra Details:
- RMC-6236 is broad spectrum inhibitor of both mutant and wild-type KRAS, NRAS, and HRAS variants.1,2 It binds with high affinity to cyclophilin A (KD = 55 nM) creating a binary complex that has high affinity for the active state of KRAS (KD = 131 nM for G12V, 364 nM for G12D and 154 nM for wild type). Active in in vivo xenograft models of NSCLC, PDAC, colorectal cancer, gastric carcinoma, and ovarian adenocarcinoma.2
- Shipping Conditions:
- Ambient