10-3975
DMB
Size
£173.00
- SKU:
- 10-3975
- Additional Names:
- 6,7-Dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline
- Physical State:
- Solid
- Molecular Weight:
- 348.2
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 281209-71-0
- Extra Details:
- DMB is a small molecule glucagon-like peptide 1 (GLP-1) ago-allosteric modulator and agonist (EC50 = 101 nM).1 It significantly stimulated insulin secretion in BRIN-BD11 cells and decreased overall glucose excursion in mice.2 DMB is a direct and selective gasdermin D (GSDMD) agonist that activates GSDMD pore formation and pyroptosis without cleaving GSDMD (EC50 = 700 nM).3 It induced pyroptosis in mouse cancer cell lines and induced tumor regression and enhanced antitumor immunity. DMB-treated tumor cells acted as a tumor vaccine in mice indicating that DMB can trigger immunogenic cell death that provides protective antitumor immunity.
- Shipping Conditions:
- Ambient