10-3974
Ceapin-A7
Size
£173.00
- SKU:
- 10-3974
- Physical State:
- Solid
- Molecular Weight:
- 470.33
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2323027-38-7
- Immunogen:
- ER/Golgi|Transcription factor|UPR (Unfolded Protein Response)
- Extra Details:
- Selective inhibitor (IC50 = 590 nM) of transcription factor ATF6A Alpha, one of the three branches of the unfolded protein response.1 It inhibits activation of ATF6A Alpha in response to ER stress without inhibiting ER-bound transcription factors ATF6B Beta or SREBP or the IRE1 or PERK branches of the UPR. Ceapin-A7 also show no toxicity to unstressed cells. It induces neomorphic association of the ER and peroxisomes by directly tethering the cytosolic domain of ATF6a to the peroxisomal transporter ABCD3 without inhibiting its transporter activity.2 See companion activator 10-3973.
- Shipping Conditions:
- Ambient