10-3961
Trametiglue
Size
£197.00
- SKU:
- 10-3961
- Additional Names:
- APS-9-95-1
- Physical State:
- Solid
- Molecular Weight:
- 666.47
- Purity:
- >98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2666940-97-0
- Immunogen:
- Kinase|Molecular glue
- Extra Details:
- Trametiglue is a trametinib analog that inhibits both KSR- and RAF-bound MEK and limits adaptive resistance seen with trametinib via enhanced interfacial binding. Displays significantly enhanced inhibition of RAS/ERK signaling versus trametinib is various cell lines with mutant KRAS and BRAF: IC50's/cell line - SK-MEL-239/0.47 nM; HCT116/0.07 nM; A549/0.12 nM; A375/0.07 nM. A molecular glue that is strongly selective towards MEK with no direct interaction with BRAF or CRAF.
- Shipping Conditions:
- Ambient