10-3954
RMC-7977
Size
£177.00
- SKU:
- 10-3954
- Physical State:
- Solid
- Molecular Weight:
- 865.11
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2765082-12-8
- Immunogen:
- GTPase|Molecular glue
- Extra Details:
- RMC-7977 is broad spectrum inhibitor of both mutant and wild-type KRAS, NRAS, and HRAS variants.1 It binds with high affinity to cyclophilin A (KD = 195 nM) creating a binary complex that has high affinity for the active state of KRAS (KD = 85 nM for G12V). Active in in vivo xenograft models of NSCLC, CRC, and PDAC.1,2,3 RMC-7977 was able to overcome resistance to the KRASG12D selective inhibitor MRTX1133.1
- Shipping Conditions:
- Ambient